Testing drugs against your cancer…but not on you.
What we do is implant your tumor in special immunodeficient mice, test multiple drugs concurrently on your tumor tissue in those mice, and report the findings to your oncologist.
It’s a simple premise. Cancer drugs are powerful…and numerous. So it’s important to find out which ones will be most effective for you, but without exposing you unnecessarily to multiple toxic drugs. By testing in mice, we can test several drugs at the same time. Think of it like five or six different cancer treatment protocols all happening concurrently, and without you. And faster (and safer!) than if tested one at a time.
While it’s a simple premise, it’s not easily done. First, we do it differently, implanting your tumor tissue not merely in mice but in the correct place (orthotopically) in the mice. For example, a pancreatic tumor gets implanted in the mouse’s pancreas. Science shows that this provides the highest clinical relevance and correlation between the patient-derived xenografts (tissue grafted into another species), which you can read about here. But it requires a great deal of precision and skill. Today, we’re the only laboratory doing orthotopic implantation surgeries on mice for the purpose of testing drug therapies.
Start earlier and get the results to your doctor as soon as possible.
With orthotopic xenografts, and with our advanced precision, we’re also able to establish tumor lines in the mice not just from surgical samples of your tumor but with tissue from a core needle biopsy. This means we can begin tumor line establishment as early as possible, which in turn means your doctor gets the results as soon as possible, often much sooner than it would otherwise be.
What we do: It’s about time.
When it comes to cancer, time is everything. First off, you want more time with the people you love. You also want the time you have to be quality time, which is a strong reason for wanting to avoid treatments that won’t work well against your cancer but will expose you to toxicity and side effects.
At Certis, a key part of what we do is to minimize the time it takes to get you into the right treatment for you. Earlier start with core needle biopsy. Faster establishment of the tumor line. Concurrent testing. Multiple mice per line to minimize time delays due to loss (normal and expected). Highest clinical relevance to minimize time wasted on bad data or restarts.
For more information about Certis’ testing, the science behind it, or how to get started, call 858-228-4110.