Reduce your time—and toxic exposure—in cancer treatment that doesn’t work.

Take the fast track to identifying the most effective therapies for you.

 

What We Do

Test multiple therapies concurrently on your cancer…but not on you.

Cancer treatment has advanced significantly, and it continues to. But cancer is enormously complex, in large part because each person’s cancer is as individual as they are. Cancer treatment remains imprecise when it comes to knowing which therapies will be most effective in fighting your cancer.

To help your doctor find the drug therapies that will work best for you, we obtain tissue from your tumor, grow it in very special mice, and test several drugs on it—at the same time. Then we provide the results your doctor needs to provide the most individualized treatment…and the hope you need and deserve.

5 stars

“I really appreciate Certis’ approach to patient communication. We’ve received regular emails from their team keeping us apprised of the progress every step of the way. They have really given me a lot of hope that my mom could actually beat this cancer.”  – J. Chen

5 stars

“I really appreciate Certis’ approach to patient communication. We’ve received regular emails from their team keeping us apprised of the progress every step of the way. They have really given me a lot of hope that my mom could actually beat this cancer.”  – J. Chen

Finding Your Most Personalized Cancer Treatment

Step 1

tumor location graphic

We obtain tissue from your tumor.

Step 2

tumor location in mouse graphic

We surgically implant your tumor in mice, where it grows and becomes established in a few months.

Step 3

mouse testing process graphic

We test multiple drug therapies on your tumor in multiple mice–at the same time.

Step 4

pill process graphic

We give your doctor accurate data about which drugs work best at fighting your cancer.

What It Does

Find new hope for more time and a higher quality of life in the fight against your unique stage 2, 3 or 4 cancer.

Our testing reduces the time needed to get you the most personalized and effective treatment for your stage 2, 3 or 4 solid-tumor cancer. We arm your doctor with the scientific data about how different drug therapies affect your tumor’s size, growth, biomarkers and more.

Knowing which therapy to use against your one-of-a-kind cancer minimizes the toxicity and wasted time of treatments that are less effective—or ineffective. This can give you more precious time, give you a higher quality of life, and offer your best chance for remission.

How It Works

Orthotopic PDXs provide the fastest, most accurate test results.

We implant your tumor tissue into immunodeficient mice. These patient-derived xenografts (PDXs) are implanted orthotopically (meaning “in the correct place”) rather than simply under the skin (subcutaneously). For example, we implant your liver tumor in the mouse’s liver.

Orthotopic PDXs provide better clinical relevance and test accuracy than subcutaneous PDXs. Simply put, to a very high degree, what happens in the mice happens in the patient. Orthotopic PDXs also allow for significantly shorter time between implantation. In addition, because orthotopic PDXs metastasize more similarly to human tumors than subcutaneous PDXs, they provide excellent clinical relevance for both primary and metastatic tumors.

tumor location in mouse graphic

Implanting your tumor tissue into the right place in your “mouse avatars” provides faster establishment and earlier, more reliable data for your doctor.

tumor location in mouse and patient graphic

With orthotopic placement, the graft has the highest correlation between your tumor and its engraftments in the mice. Simply, what happens in the mice is, to a very high degree, what would happen in you.

doctor working on mouse tumor graphic

Rather than on you, testing takes place in the mice, whom we care for to the highest standards in our state-of-the-art, in-house vivarium.

tumor location in mouse graphic

Implanting your tumor tissue into the right place in your “mouse avatars” provides faster establishment and earlier, more reliable data for your doctor.

mouse and human tumor graphic

With orthotopic placement, the graft has the highest correlation between your tumor and its engraftments in the mice. Simply, what happens in the mice is, to a very high degree, what would happen in you.

doctor working on mouse tumor graphic

Rather than on you, testing takes place in the mice, whom we care for to the highest standards in our state-of-the-art, in-house vivarium.

Scientifically Proven

Validated by dozens of peer-reviewed studies and already benefitting lives.

Our approach to evaluating drug therapies on patients’ own tumors in “mouse avatars” has been validated in more than 40 different scientific studies published in peer-reviewed journals. In addition, our testing has already prolonged and improved lives, and the data from our studies has allowed the use of off-label drugs to expand the possibilities for individualized cancer therapies.

cancer cells

Are You a Candidate?

Real hope for more time and a higher quality of life starts here.

Certis’ orthotopic PDX testing is an option for certain cancers (see list here) in specific situations. Your tumor cannot have been recently treated with radiation, and tumor implantation and testing only work with solid-tumor-type, stage 2, 3 or 4 cancers. Yet, within these constraints, we’re still able to test a wide range of adult and pediatric cancer types.

cancer cells

What to Expect

Laboratory testing means maximum safety, faster results, and an easy process for you.

Certis’ testing is for you, but it isn’t on you. Your doctor provides us your tumor tissue through surgical sample or core needle biopsy, and then we establish the tumor line in the mice…in just a few months (compared to 6 to 9 months for subcutaneous PDXs). From there, we perform all testing on your mouse avatars. For you, no time, no travel, and no toxicity related to our testing.

Tumor Cryopreservation

Cryopreserved tumor tissue can help benefit testing—and treatment—later on.

At Certis, we cryopreserve tumors for xenograft testing later if warranted. But tumor cryopreservation—a very specialized form of careful “freezing” that maintains cellular viability—has other benefits. Having your tumor cryopreserved now provides a baseline comparison for later and faster response to qualify for clinical trials. Cryopreserved tumor tissue can also be used later if you’re too sick for a biopsy, and it can reduce the time to tumor establishment for future xenograft testing.

Microscopic image of cells
Microscopic image of cells

Tumor Cryopreservation

Cryopreserved tumor tissue can help benefit testing—and treatment—later on.

At Certis, we cryopreserve tumors for xenograft testing later if warranted. But tumor cryopreservation—a very specialized form of careful “freezing” that maintains cellular viability—has other benefits. Having your tumor cryopreserved now provides a baseline comparison for later and faster response to qualify for clinical trials. Cryopreserved tumor tissue can also be used later if you’re too sick for a biopsy, and it can reduce the time to tumor establishment for future xenograft testing.

About Certis

An expert team dedicated to innovation, excellence and improving and extending your life.

Certis Oncology Solutions is directed and advised by cancer experts, including leaders who have collaborated on cancer research with UCLA and Memorial Sloan Kettering Cancer Center. We’ve introduced techniques that have expanded cancer care, and our state-of-the-art lab is fully licensed and CLIA-certified for high-complexity testing, the highest level of certification.

We also care for the mice to the highest standards in our in-house, AALAC-accredited vivarium. In addition, we maintain our own tumor bank, where we not only preserve tumor tissue for future research, but also cryopreserve some of your tumor for later testing, if needed.

microscope research image

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