Are you a candidate for Certis’ orthotopic PDX testing?

Orthotopic PDX testing on tumor tissue in mice is appropriate for many different types of stage 2, 3 and 4 cancer. However, it is not appropriate for all cancer patients. So, are you—or is the person you’re thinking of—a candidate for this advanced testing?

5 stars “I really appreciate Certis’ approach to patient communication. We’ve received regular emails from their team keeping us appraised of the progress every step of the way. They have really given me a lot of hope that my mom could actually beat this cancer.” – J. Chen


Criteria for eligibility for Certis Oncology Solutions’ orthotopic PDX testing.

Our testing may be appropriate for you if you meet the following criteria:

  • Adult & Pediatric Cancers – Orthotopic PDX testing has been shown to provide reliable accuracy for children as well as adults.
  • Primary or Metastatic Tumors – Tumor tissue implanted orthotopically (“in the correct place”), once fully established, metastasizes similarly to the patient’s own tumor. This is not true of ectopic (“in the wrong place”) xenografts. As a result, Certis’ testing yields reliable results for metastatic tumors, not just primary tumors.
  • Stage 2, 3 & 4 Cancers – Orthotopic implantation and establishment of multiple tumor lines in mice can only be done on tumors that are developed enough (have an adequate number of cells). This leaves out stage 1 cancers.
  • Solid-Tumor Cancers – Our testing is on tumor tissue that gets implanted and grows in laboratory mice. Non-solid-tumor-type cancers can’t be implanted or established.
  • Sarcoma-Type Cancers – Sarcomas grow in connective tissue and are rarer than carcinomas. The biology of sarcoma makes PDX testing possible, unlike with carcinoma.
  • Tumors That Haven’t Been Irradiated – Radiation therapy, also known as radiotherapy, is a common treatment for many types of cancer. Unfortunately, radiation destroys the cells’ nucleotide bonds, preventing the tumor from establishing.
  • Tumors That Have Been Previously Treated – Being in—or having previously been in—cancer treatment does not disqualify you for Certis’ advanced testing (radiation therapy excepted). Prior treatment can have an effect on establishment of your tumor in mice, but it does not prevent it.

There are other factors that affect candidacy for this test, so please call us at 858-228-4110 or talk to your doctor about your eligibility.

A viable option for a wide range of primary and metastatic cancers.

While various factors mean that we can’t perform testing for all cancer patients, orthotopic PDX testing remains a viable alternative for many people with rare and aggressive cancers who are looking for an edge in their fight. As such, we can help your doctor give you new hope for more time and a higher quality of life for cancers of the:

  • Colon
  • Liver
  • Brain
  • Pancreas
  • Lung
  • Ovaries
  • Breast
  • Sarcoma

For more information about Certis’ testing, your (or your loved one’s) eligibility, or how to get started, call 858-228-4110.